预防风险青少年的抑郁症:一个随机对照试验
Judy Garber1, Gregory N Clarke, V Robin Weersing
1Department of Psychology and Human Development, Vanderbilt University, 552 Peabody, 230 Appleton Pl, Nashville, TN 37203-5721, USA. judy.garber@vanderbilt.edu
JAMA
|June 4, 2009
概括
一组认知行为 (CB) 预防计划减少了风险青少年的抑郁症发作. 然而,对于那些父母目前处于抑郁状态的人来说,该计划的效果不那么好.
科学领域:
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
- 临床心理学 临床心理学
背景情况:
- 抑郁症父母的青少年后代面临患抑郁症的风险更高.
- 以前的小规模预防试验显示出有希望,但结果需要在更大,更多样化的群体中复制.
研究的目的:
- 评估一组认知行为 (CB) 预防计划在预防风险青少年抑郁症发作的有效性.
- 为了比较CB计划的有效性与常规护理.
主要方法:
- 一个多中心随机对照试验,涉及316名青少年 (年龄13-17岁),父母有抑郁病史.
- 参与者被分配到一个为期8周的小组CB计划,每月随访或通常的护理.
- 结果包括通过临床访谈诊断的可能或确定的抑郁发作的发生率和危险比率.
主要成果:
- 与常规护理 (32.7%) 相比,CB计划组的抑郁发作发病率较低 (21.4%),危险比率为0.63.7%.
- 在CB计划中的青少年报告说,抑郁症状的改善显著更大.
- 干预的有效性受到父母抑郁状态的调节;当父母在基线没有抑郁时,该计划更有效.
结论:
- 群体认知行为 (CB) 预防计划在9个月内对抑郁症发作和症状改善产生了显著的预防作用.
- 在青少年中没有观察到预防作用,他们的父母目前处于抑郁状态.
- 研究结果强调了在青少年抑郁症预防策略中考虑父母心理健康的重要性.
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