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Updated: Jun 22, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

雷斯是一种状特异性蛋白质,调解了突变猎素细胞毒性

Srinivasa Subramaniam1, Katherine M Sixt, Roxanne Barrow

  • 1Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Science (New York, N.Y.)
|June 6, 2009
PubMed
概括

亨廷顿病 (HD) 病理局限于条纹体,这是由于突变的亨廷丁 (mHtt) 与条纹体特异性蛋白Rhes.之间的相互作用造成的. 结合Rhes诱导mHtt的sumoylation,导致细胞死亡,并解释了HD选择性脑区域的影响.

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