化复合物与Ph3SiO连接物是极其实用和耐受的基转化前催化剂和高效的转移剂
Martin Bindl1, Robert Stade, Eike K Heilmann
1Max-Planck-Institut fur Kohlenforschung, D-45470 Mulheim/Ruhr, Germany.
Journal of the American Chemical Society
|June 19, 2009
概括
新的化复合物在基基转化中表现出极好的催化活性. 一个复合体,体11,是稳定的空气和宽泛的功能性组耐受性,简化其在合成复杂分子的使用.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
背景情况:
- 基基因转化是有机合成中的关键反应.
- 现有的基基转化预催化剂往往缺乏稳定性或易于处理.
研究的目的:
- 开发用于基转基因的基于化的新型,稳定和高度活性的前催化剂.
- 评估这些新系统的催化性能和功能组耐受性.
主要方法:
- 在现场制备的化复合物[{Ph}{3}SiO) {3}Mo[三键]N] (10) 从[{Me}{3}SiO) {2}{Me}{3}Si) {2}N) {3}Mo[三键]N] (9) 和Ph{3}SiOH.
- 形成和分离的皮里丁添加物[pyridine]{pyridine}{Ph}{3}SiO){3}Mo[三键]N] (11) 的形成和分离.
- 在各种基转化反应中测试复合物10和11的催化活性.
主要成果:
- 复合物10及其胺添加物11在各种基因转化反应中表现出极好的催化活性.
- Adduct 11是稳定的空气和易于处理,超过现有的预催化剂在可用性.
- 催化系统显示了广泛的功能组兼容性,包括,胺和受保护的酒精.
- 成功合成生物活性天然产品的关键中间体,如epothilone A和latrunculin类似物.
结论:
- 新型化复合物,特别是稳定于空气的合物11,代表了基转化催化学的重大进步.
- 这些预催化剂提供了增强的稳定性,易于使用和广泛的基质范围,促进复杂有机分子的合成.
- 该系统与各种功能组的兼容性使其成为合成化学家的一种多功能工具.
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