风险评分用于预测无症状大动脉狭窄症患者的结果
Jean-Luc Monin1, Patrizio Lancellotti, Mehran Monchi
1Department of Cardiology, Henri Mondor Hospital, 51 avenue De Lattre de Tassigny, 94010 Créteil, France. jean-luc.monin@hmn.aphp.fr
Circulation
|June 24, 2009
概括
新的风险评分有助于预测无症状严重大动脉狭窄症患者的症状或不良事件. 该工具有助于识别可能受益于早期手术干预的个体.
科学领域:
- 心脏病学 心脏病学
- 膜心脏疾病 膜心脏疾病
- 医学风险分层医学风险分层.
背景情况:
- 无症状的严重大动脉狭窄症的管理具有挑战性.
- 预测症状发作或不良事件对于及时干预至关重要.
研究的目的:
- 开发和验证无症状严重大动脉狭窄症的持续风险评分.
- 为了确定患有中期不良结果风险较高的患者.
主要方法:
- 对107名患有无症状严重大动脉狭窄症的患者进行前性队列研究.
- 使用独立预测因素制定风险评分:女性性别,最大主动脉喷射速度和B型尿素.
- 在107名患者的独立队列中验证.
主要成果:
- 风险评分独立预测了不良结果 (死亡或症状驱动的大动脉置换).
- 在20个月的无事件存活率在各分数四分位数之间有显著差异 (80%与7%相比).
- 通过ROC曲线证明的高预测准确度 (在开发和验证队列中为0.90和0.89).
结论:
- 开发的风险评分显示了预测无症状严重大动脉狭窄的结果的潜力.
- 这一分数可能有助于选择可能受益于早期手术干预的患者.
- 建议对临床实施进行进一步的验证.
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