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相关概念视频

Channel Rhodopsins01:11

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...

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Proton Transfer and Protein Conformation Dynamics in Photosensitive Proteins by Time-resolved Step-scan Fourier-transform Infrared Spectroscopy
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聚合物微囊的光驱释放功能化与bacteriorhodopsin.

Svetlana Erokhina1, Lucia Benassi, Paolo Bianchini

  • 1Department of Biochemistry and Molecular Biology, University of Parma, Viale Usberti 23 A, 43100 Parma, Italy.

Journal of the American Chemical Society
|June 27, 2009
PubMed
概括
此摘要是机器生成的。

聚合物囊中的Bacteriorhodopsin控制着光线的孔隙开放,使囊染料的pH触发释放成为可能. 这表明了一种新的光响应药物递送系统.

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科学领域:

  • 生物材料科学 生物材料科学
  • 摄影化学的使用.
  • 纳米技术 纳米技术

背景情况:

  • 聚合物囊在药物输送方面得到了广泛的研究.
  • 控制封装物质的释放仍然是一个挑战.
  • 底素是一种光激活的质子,具有对响应性材料的潜力.

研究的目的:

  • 为了将bacteriorhodopsin纳入聚合物囊外.
  • 为了研究光引起的囊性质的变化.
  • 为了证明封装分子的受控释放.

主要方法:

  • 将bacteriorhodopsin纳入聚合物囊的外.
  • 扫描电子显微镜 (SEM) 用于观察囊间体积和孔隙开口的光驱变化.
  • 同焦光显微镜用于监测封装染料分子的释放.

主要成果:

  • 成功地将bacteriorhodopsin纳入聚合物囊外中.
  • 通过SEM证明光引起的pH值变化和囊中的连续孔隙开放.
  • 使用共聚焦光显微镜观察封装染料分子的受控释放.

结论:

  • 细菌原素功能化的聚合物囊表现出对光敏感的行为.
  • 该系统允许控制孔隙打开和释放封装的内容.
  • 这为光控制药物递送系统提供了一个有前途的平台.