相关实验视频

Updated: May 12, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

通过素H3和H4进行DNA的特定折叠和收缩

M Bina-Stein, R T Simpson

    Cell
    |July 1, 1977
    PubMed
    概括

    富含氨酸的基因组H3和H4紧了DNA,引入了扭曲约束,形成了类似于核细胞的结构. 这些组织蛋白是染色质核颗粒中DNA结构的关键.

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    相关概念视频

    DNA Packaging00:58

    DNA Packaging

    Overview
    DNA Packaging00:58

    DNA Packaging

    Overview
    The Nucleosome02:33

    The Nucleosome

    DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
    DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
    Chromatin Packaging02:21

    Chromatin Packaging

    Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
    The chromatin
    In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
    The Nucleosome02:33

    The Nucleosome

    DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
    DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
    The Nucleosome01:19

    The Nucleosome

    Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
    In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...