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Published on: February 15, 2015
规则导向行为的可分离组件取决于不同的中间和前额区域
Mark J Buckley1, Farshad A Mansouri, Hassan Hoda
1Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK. buckley@psy.ox.ac.uk
概括
主损伤影响了工作记忆中的规则维护,轨道前皮层损伤影响了基于奖励的规则更新,ACC损伤影响了决策选择结果的引用.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 灵长类神经生理学
背景情况:
- 规则引导的行为对于复杂的决策至关重要.
- 众所周知,前额皮层 (PFC) 和前环皮层 (ACC) 实施规则引导行为.
- 在PFC和ACC内部的具体区域贡献仍然不清楚.
研究的目的:
- 阐明特定前额和ACC子区域在规则引导行为中的不同作用.
- 为了弥合人类神经心理学和非人类灵长类神经生理学之间的发现.
- 为了研究局限性损伤对规则导向决策的认知组成部分的影响.
主要方法:
- 使用了威斯康星州卡片排序测试 (WCST) 模拟在.
- 对特定的大脑区域进行了局限性损伤:轨道前皮层 (OFC),主 (PS),上背侧,腹侧和ACC.
- 评估了伤害后规则引导行为的可分离的认知组成部分.
主要成果:
- 主 (PS) 病变特别影响了工作记忆中的抽象规则的维护.
- 轨道前皮层 (OFC) 病变选择性地破坏了基于奖励的规则值表示的快速更新.
- 前带带皮层 (ACC) 硫病变损害了决策过程中对最近的选择结果的积极引用.
结论:
- 不同的PFC和ACC分区在实施规则引导行为方面发挥着不同的关键作用.
- PS对于规则维护至关重要,OFC对于价值更新至关重要,ACC sulcus对于基于结果的决策至关重要.
- 这些发现为理解神经疾病中观察到的规则导向行为的缺陷提供了神经生理学的基础.
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