阿迪波涅克丁水平和2型糖尿病的风险:系统性审查和元分析
Shanshan Li1, Hyun Joon Shin, Eric L Ding
1Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
JAMA
|July 9, 2009
概括
较高水平的阿迪波涅丁,一个关键的阿迪波金,始终与降低患2型糖尿病的风险有关. 这种反向关系在各种人群和研究设计中都是真实的.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 肥胖与2型糖尿病的风险增加有关,可能由改变的阿迪波金分泌物介导.
- 阿迪波尼克丁是一种具有抗炎和胰岛素敏感性质的阿迪波金,在更大的脂肪性下降调节.
- 血腺素水平与2型糖尿病风险之间的确切关系需要澄清.
研究的目的:
- 系统地审查前性研究,调查血腺素水平与2型糖尿病风险之间的关联.
- 综合证据证明这种关系在不同人群中的一致性和强度.
主要方法:
- 对主要科学数据库 (MEDLINE,EMBASE,科学引用指数扩展) 进行了全面的系统搜索.
- 包括前性研究,测量血腺素和跟踪2型糖尿病发病率.
- 数据提取和质量评估是独立进行的;元分析使用随机效应模型和一般化最小平方趋势估计进行剂量反应分析.
主要成果:
- 包括13项前性研究,包括14598名参与者和2623例2型糖尿病病例.
- 观察到一个显著的反向,单调的关联:较高的阿迪波涅丁水平与较低的2型糖尿病风险相关 (RR 0.72每1日志增量).
- 这种反向关联在不同种族 (白人,东亚人,亚洲印第安人,非洲裔美国人,美洲原住民) 和各种研究参数中是一致的.
结论:
- 血腺素水平升高与患2型糖尿病的风险降低密切相关.
- 这些发现支持了一种一致的剂量反应关系,表明较高的阿迪波内克可能会对2型糖尿病产生保护作用.
- 这种关联在广泛的人群中是显而易见的,这强调了阿迪波涅丁在预防糖尿病方面的潜在作用.
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