成年海马神经发生在空间模式分离中的功能作用
C D Clelland1, M Choi, C Romberg
1Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Science (New York, N.Y.)
|July 11, 2009
概括
牙状回形 (DG) 中的新生儿神经元对于模式分离至关重要,使不同的记忆表现成为可能. 成年小鼠的消灭神经发生特别损害了需要细粒度空间区分的空间区分任务.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 河马功能 河马功能
背景情况:
- 牙状 (DG) 在记忆形成中起着关键作用.
- 成年海马神经发生,新神经元的诞生,发生在整个生命.
- 神经生成对DG功能的确切贡献仍然不清楚.
研究的目的:
- 研究成人海马神经发生在模式分离中的作用.
- 确定新生儿神经元是否对于总局在区分类似的空间信息方面的功能是必要的.
主要方法:
- 使用了经过实验废除的海马神经发生的成年小鼠.
- 使用两个不同的行为范式评估空间区分能力:辐射臂迷宫和触摸屏任务.
- 当刺激在空间分离上有所不同时,具有和没有神经发生的小鼠之间的性能比较.
主要成果:
- 缺乏海马神经发生的小鼠在空间区分任务中表现出显著的损伤.
- 当刺激与最小的空间分离呈现时,缺陷最明显.
- 当刺激在空间上不同时,表现不受影响.
结论:
- 成年海马神经发生是正常模式分离功能在牙状环中必不可少的.
- 新生儿的神经元对于形成类似的记忆信息的独特表示至关重要.
- 这些发现凸显了成年海马体中正在进行的神经发生的功能重要性,这对认知过程至关重要.
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