高血压和动脉样硬化. 原因和后果,还是两个后果与一个未知的原因?
G Bondjers1, M Glukhova, G K Hansson
1Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Sweden.
Circulation
|December 1, 1991
概括
高血压 (高血压) 和动脉样硬化共享细胞缺陷,这表明它们有共同的起源. 了解这些细胞过程是预防心血管疾病和改善抗高血压治疗的关键.
科学领域:
- 心血管科学 心血管科学
- 细胞生物学 细胞生物学
- 动脉样硬化的发病因子
背景情况:
- 高血压通过动脉样硬化增加心血管风险.
- 抗高血压治疗在降低这种风险方面取得了有限的成功.
- 动脉样硬化的细胞机制需要进一步研究.
研究的目的:
- 审查动脉样硬化病变中的细胞过程.
- 为了强调平滑肌肉细胞在高血压和动脉样硬化中的作用.
- 为了探索两种情况共同的潜在细胞缺陷.
主要方法:
- 关于细胞动脉动脉生成的现有文献的综述.
- 对动脉样硬化病变内的细胞群的分析.
- 关于光滑肌肉细胞的增殖和反应性的讨论.
主要成果:
- 内皮和光滑肌肉细胞在动脉生成过程中发生变化.
- 淋巴细胞和单细胞在脂质积累和细胞增殖中起着至关重要的作用.
- 顺肌细胞是动脉样硬化病变和高血压血管的主要组成部分.
结论:
- 存在两种平滑肌肉细胞种群扩张的机制:干细胞增殖或分化细胞增殖.
- 改变细胞对刺激的反应性可能会将高血压和动脉样硬化联系在一起.
- 高血压和动脉样硬化可能是共享细胞缺陷的表现,影响冠心病预防策略.
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