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治疗严重急性营养不良的益生菌和益生菌 (PRONUT研究):马拉维的一项双盲有效性随机对照试验
Marko Kerac1, James Bunn, Andrew Seal
1Valid International, Oxford, UK. marko.kerac@gmail.com
Lancet (London, England)
|July 15, 2009
概括
益生菌和益生菌功能食品没有改善马拉维儿童严重急性营养不良的营养结果. 需要进一步的研究来探索减少门诊死亡率的潜在益处.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 传染病流行病学 传染病流行病学
背景情况:
- 严重急性营养不良 (SAM) 是一个关键的全球健康问题,每年造成数百万人的死亡.
- 该研究涉及SAM治疗在艾滋病毒流行率高的环境中.
- 研究SAM的新型治疗干预措施至关重要.
研究的目的:
- 评估一种协生功能食品 (Synbiotic2000 Forte) 的临床和营养疗效,用于治疗SAM.
- 评估Synbiotic2000 Forte在艾滋病毒流行人口中的影响.
- 为了确定Synbiotic2000 Forte是否可以提高治愈率并降低SAM病例的死亡率.
主要方法:
- 这是一项双盲,随机,安慰剂对照试验,涉及795名5至168个月龄的马拉维儿童.
- 儿童接受了标准的准备好使用的治疗食品,有或没有Synbiotic2000 Forte后稳定.
- 主要结局是营养治疗;次要结局包括死亡率,体重增加和症状患病率.
主要成果:
- 在Synbiotic2000 Forte组 (53.9%) 和安慰剂组 (51.3%) 之间,营养治愈率没有显著差异.
- 二次结果,包括死亡率和治愈时间,在两组之间是相似的.
- 艾滋病毒阳性与较差的结果有关,但没有改变该研究的主要发现.
结论:
- 在这个马拉维队列中,Synbiotic2000 Forte没有证明严重急性营养不良的临床或营养结果有所改善.
- 在共生组中减少门诊死亡率的潜在趋势需要进一步调查.
- 未来的研究应该探索协生菌对SAM相关死亡率的生物可信性和公共卫生影响.
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