相关实验视频
精神分裂症患者死亡率的11年随访:基于人口的队列研究 (FIN11研究)
Jari Tiihonen1, Jouko Lönnqvist, Kristian Wahlbeck
1Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland. jari.tiihonen@niuva.fi
Lancet (London, England)
|July 15, 2009
概括
在精神分裂症患者中,长期使用抗精神病药物治疗与降低死亡率有关. 与其他抗精神病药物相比,克洛扎宾的死亡风险明显较低,这表明需要重新评估其使用限制.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学 是一个学科.
- 公共卫生 公共卫生
背景情况:
- 20世纪90年代推出第二代抗精神病药物引发了人们对其对精神分裂症患者死亡率的影响的担忧.
- 这项研究旨在确定抗精神病药物使用对精神分裂症患者死亡率的长期影响.
研究的目的:
- 调查抗精神病药物使用与精神分裂症患者死亡率之间的长期关联.
- 为了比较与特定抗精神病药物和不同使用时间相关的死亡风险.
主要方法:
- 从1996年到2006年,利用全国性的芬兰登记册来比较66881名精神分裂症患者和普通人口 (5,200万) 之间的特定原因死亡率.
- 将死亡率数据与抗精神病药物处方记录联系起来,分析基于当前和累积暴露与不使用的全因死亡率.
- 频繁使用的抗精神病药物的死亡风险与perphenazine相比.
主要成果:
- 尽管第二代抗精神病药物使用率上升 (13%至64%),但精神分裂症患者的预期寿命差距没有扩大 (25至22.5年).
- 与氨酸相比,克洛沙使用与死亡风险最低 (HR 0.74),而氨酸显示死亡风险最高 (HR 1.41).
- 长期累积抗精神病药物暴露 (7-11年) 与较低的死亡率 (HR 0.81) 有关,死亡率与使用时间之间的关系是逆的.
结论:
- 与不使用药物相比,长期的抗精神病治疗与精神分裂症患者的死亡率降低有关.
- 第二代抗精神病药物是一个异质的群体;克洛扎宾的死亡风险明显低于其他抗精神病药物.
- 目前对克洛沙使用的限制需要重新评估,因为它具有有利的死亡率.
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