.

Hannah L Klein1, Lorraine S Symington

  • 1Department of Biochemistry, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA. hannah.klein@nyumc.org

Cell
|July 15, 2009
PubMed
概括

人类SLX4蛋白质充当了酶的支架. 它与SLX1内核酶一起工作,以解决复杂的DNA结构,称为霍利代结.

相关概念视频

Social Exchange Theory02:06

Social Exchange Theory

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Leaving Groups02:14

Leaving Groups

The nature of leaving groups strongly influences the outcome of a nucleophilic substitution reaction.
In general, in a nucleophilic substitution reaction, a nucleophile displaces a functional group, called the leaving group, from the substrate to give a substituted product. A leaving group departs the substrate molecule through heterolytic cleavage, taking the pair of electrons with it to become a relatively stable weak base in the form of an anion or a neutral molecule.  
In a nucleophilic...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

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At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Social Exchange Theory01:26

Social Exchange Theory

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Ending Relationships01:28

Ending Relationships

The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...