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Updated: Jun 21, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

来自α,β不和脂肪酸的盐酸胺的生物合成:对扩大聚基酸合成酶多样性的影响

Yuan Liu1, Christopher Hazzard, Alessandra S Eustáquio

  • 1Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA.

Journal of the American Chemical Society
|July 16, 2009
PubMed
概括

研究人员在海洋细菌中发现了新型的辅酶A扩展单元,对于合成沙利诺胺抗癌药物至关重要. 酶SalG在加工基质方面表现出灵活性,影响药物结构.

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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

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