系统地检查更新的弗雷明汉心脏研究的一般心血管风险概况
Amanda K Marma1, Donald M Lloyd-Jones
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Dr, Suite 1102, Chicago, IL 60611, USA.
Circulation
|July 22, 2009
概括
更新的Framingham风险工具显示,年龄是关键因素,但吸烟和糖尿病等高风险因素可能会影响年轻人. 血管年龄沟通有助于理解风险.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 风险评估 风险评估
背景情况:
- 一个新的Framingham风险预测工具结合了一般心血管疾病的终点.
- 它为风险沟通引入了一个"血管年龄"概念.
研究的目的:
- 分析风险因素组合及其对心血管风险值的影响.
- 了解不同风险因素负担如何转化为"血管年龄".
主要方法:
- 系统检查更新的风险预测工具.
- 改变个体和组合风险因素水平以观察预测的风险输出.
- 将高风险定义为10年预测风险>=20%.
主要成果:
- 年龄是两性10年心血管风险的主要决定因素.
- 具有多种风险因素的年轻人可能仍然预测风险较低.
- 高风险 (>=20%) 可能发生在35岁的男性和40岁的女性中,具有显著的风险因素 (吸烟,糖尿病).
- 预测10年风险范围为3.1%至46.8%的45岁男性和2.4%至42.7%的55岁女性.
- 血管年龄差异很大,45岁的男性从37岁到80岁以上,55岁的女性从39岁到80岁以上.
结论:
- 该工具的扩展终点增加了跨年龄段预测的风险范围.
- 年轻的个体具有实质性风险因素可能呈现低10年风险.
- "血管年龄"指标提供了一种广泛的沟通工具,用于跨时间年龄的心血管风险.
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