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Updated: Jun 21, 2026

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
07:42

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Published on: June 29, 2011

XIAP区分了FAS诱导的I型和II型亡

Philipp J Jost1, Stephanie Grabow, Daniel Gray

  • 1The Walter and Eliza Hall Institute of Medical Research, Melbourne University, Parkville, Victoria 3050, Australia.

Nature
|July 24, 2009
PubMed
概括

失去了XIAP (X染色体相关的亡蛋白抑制剂) 功能使得肝脏和β细胞在没有BID的情况下触发亡. 这揭示了XIAP是亡信号差异的关键,并建议在肝脏患者中谨慎使用IAP抑制剂.

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Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...