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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

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An Aptamer-based Sensor for Unchelated Gadolinium(III)
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一个新的基于加多的MRI传感器.

Ana C Esqueda1, Jorge A López, Gabriel Andreu-de-Riquer

  • 1Departamento de Química, Universidad de Guanajuato, Cerro de la Venada s/n, Guanajuato, Gto., C.P. 36040, México.

Journal of the American Chemical Society
|July 28, 2009
PubMed
概括

一个新的基于加多 (Gd3+) 的MRI传感器,GdL,显示了增强的 (Zn2+) 检测. GdL:Zn2+复合物强烈地与人血清白蛋白 (HSA) 结合,显著增加了潜在的体内成像的MRI信号.

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科学领域:

  • 生物医学工程 生物医学工程
  • 医疗成像医学成像
  • 分析化学 分析化学

背景情况:

  • 基于加多 (Gd3+) 的药物对磁共振成像 (MRI) 对比度至关重要.
  • (Zn2+) 在生物系统中起着至关重要的作用,其失调与各种疾病有关.
  • 开发敏感和特定的MRI传感器用于生物分析物如Zn2+仍然是一个挑战.

研究的目的:

  • 报告基于Gd3+的新型MRI传感器的特性,该传感器旨在检测Zn2+.
  • 为了研究传感器与人血清白蛋白 (HSA) 和Zn2+的结合特性.
  • 为了评估传感器在体内Zn2+成像的潜力.

主要方法:

  • 基于Gd3+的新型传感器 (GdL) 的综合和描述.
  • 使用已知方法 (例如Kd确定) 评估GdL与Zn2+的结合亲和力.
  • 使用MRI对HSA结合的三元复合体 (GdL:Zn2+) 的评估及其对水质子放松性的影响.

主要成果:

  • GdL传感器对Zn2+ (Kd = 33.6 nM) 具有很强的结合亲和力.
  • GdL:Zn2+复合体表现出强烈的与HSA结合,导致水质子放松率增加了3倍.
  • 传感器检测到Zn2+度低至30微米在HSA存在的情况下在体外.

结论:

  • 新型GdL传感器在检测生物相关的自由Zn2+度方面表现有前途.
  • 强烈的HSA结合和GdL:Zn2+复合物的放松性增加促进了敏感的MRI检测.
  • 这种基于Gd3+的传感器可以在不干扰生物过程的情况下进行Zn2+的非侵入性体内成像.