,MRE11.

Yibin Deng1, Xiaolan Guo, David O Ferguson

  • 1Department of Genetics, Box 1010, The M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

Nature
|July 28, 2009
PubMed
概括

该MRN复合体对于感知功能障碍的端粒和促进DNA修复至关重要. MRE11核酶活动通过处理端粒突起来防止有害的染色体融合.

相关概念视频

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

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Replication in Eukaryotes02:31

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