在基于人口的研究中预测手臂流介导扩张发生心血管事件的预测值:动脉样硬化多民族研究
Joseph Yeboah1, Aaron R Folsom, Gregory L Burke
1Department of Internal Medicine/Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA. jy5y@hscmail.mcc.virginia.edu
Circulation
|July 29, 2009
概括
支臂动脉流介导扩张 (FMD) 预测了成人新的心血管疾病 (CVD) 事件. 将口病添加到弗雷明汉风险评分 (FRS) 提高了风险分类,有助于更好地管理患者.
科学领域:
- 血管生物学和心血管疾病研究.
背景情况:
- 众所周知,支臂动脉流介导扩张 (FMD) 可以预测复发性心血管事件.
- 它对以前没有心血管疾病的个体发生心血管疾病 (CVD) 的预测能力不太成熟.
研究的目的:
- 为了评估手臂动脉口腔炎的预测价值,对发生的心血管疾病事件.
- 评估口病对多民族动脉样硬化研究 (MESA) 队列风险分层的贡献.
主要方法:
- 分析了MESA队列中的3026名成年人的嵌套案例队列样本.
- 使用概率加权的考克斯比例危险模型来评估口病和5年判决事件心血管疾病事件之间的关联.
- 对各种风险因素和弗雷明汉风险评分 (FRS) 进行了调整.
主要成果:
- 在多变量模型中,较低的口病与发生心血管疾病事件的风险增加显著相关 (HR 0.84,P=0.04).
- 将口病添加到FRS中,导致29%的受试者净正确重新分类 (P<0.001).
- 虽然口病在ROC分析中没有改善歧视,但与单独的FRS相比,它提高了风险分类.
结论:
- 支臂动脉口腔炎是一般成年人群中发生心血管事件的预测因素.
- 将口病纳入风险评估模型中,就像FRS一样,可以改善对个体的分类,将其分为低,中等和高CVD风险类别.
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