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рибофлавин激酶对TNF受体1与NADPH氧化酶进行配对

Benjamin Yazdanpanah1, Katja Wiegmann, Vladimir Tchikov

  • 1Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

Nature
|July 31, 2009
PubMed
概括

riboflavin 激酶 (RFK) 作为连接瘤亡因子受体 1 (TNFR1) 与细胞防御中的关键酶 NADPH 氧化酶的桥梁. 这种相互作用对于TNF诱导的活性氧物种 (ROS) 生产至关重要,因为它通过增强FAD的纳入NADPH氧化酶而产生活性氧物种 (ROS).

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