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Updated: Jun 21, 2026

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

在小鼠胰腺中Pax4的异卵性表达将原始细胞转化为α细胞,随后转化为β细胞

Patrick Collombat1, Xiaobo Xu, Philippe Ravassard

  • 1Department of Molecular Cell Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg, D-37077 Göttingen, Germany. collombat@unice.fr

Cell
|August 12, 2009
PubMed
概括

Pax4基因表达可以将胰腺α细胞重新编程为β细胞,恢复β细胞质量并治愈小鼠糖尿病. 这涉及新生和重新分化的循环,突出Pax4

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Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

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In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors08:35

In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors

Published on: July 19, 2014

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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...