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Updated: Jun 21, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
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受体氨酸激酶信号的选择性由二次SH2域结合位控制

Jae Hyun Bae1, Erin Denise Lew, Satoru Yuzawa

  • 1Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Cell
|August 12, 2009
PubMed
概括

在受体氨酸激酶信号传递中,SH2域相互作用是关键. 新的研究揭示了二次结合点调节脂酶Cgamma选择性,为细胞信号通路提供了更复杂的视图.

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