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肝脏移植急性肝功能衰竭?
R W Chapman1, D Forman, R Peto
1Department of Gastroenterology, John Radcliffe Hospital, Oxford, UK.
Lancet (London, England)
|January 6, 1990
概括
肝移植是严重发性肝衰竭的一个选择. 需要进行受控试验,以确定在紧急肝移植中选择患者和治疗有效性的标准.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
- 关键的护理关键的护理
背景情况:
- 全发性肝衰竭 (FHF) 缺乏确定的医疗治疗方法,使肝移植成为精选患者的潜在选择.
- 目前对FHF严重程度和治疗结果的标准没有标准化,导致人们担心不必要的移植和符合条件的患者的治疗不足.
- 对于FHF的历史治疗方案往往缺乏强有力的证据,受控试验未能证明有益.
研究的目的:
- 强调需要统一和适用的标准来诊断FHF严重程度.
- 强调需要标准化的方法来分析接受肝移植的FHF患者的结果.
- 倡导进行受控试验,以快速确定紧急肝移植在FHF中的作用和疗效.
主要方法:
- 审查现有的文献和临床实践,关于FHF管理和肝移植.
- 确定FHF目前的诊断和预后标准的局限性.
- 关于多中心受控试验的建议,涉及专门的肝移植单位.
主要成果:
- 缺乏标准化的标准阻碍了FHF肝移植的最佳患者选择.
- 以往基于历史数据的FHF治疗方法尚未通过受控试验得到证实.
- 需要快速获取有关紧急肝移植有效性的可靠数据.
结论:
- 对FHF严重程度和移植结果的标准化标准对于适当的患者管理至关重要.
- 控制试验对于克服历史数据的局限性和建立基于证据的治疗策略至关重要.
- 迫切需要一项协作,受控试验,以确定紧急肝移植在FHF中的作用.
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