胸痛的病理生理学
Lancet (London, England)
|January 13, 1990
概括
心肌缺血不仅仅涉及氧气供需不平衡. 有效的药物治疗必须解决荷尔蒙,代谢和血液动力学变化,以逆转有害循环.
科学领域:
- 心脏病学 心脏病学
- 病理生理学 病理生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心肌缺血的发展是一个复杂的,动态的过程.
- 氧气需求和冠状动脉血流不是唯一的决定因素.
- 这些因素的异常变化引发了一个恶性循环.
研究的目的:
- 为了阐明心肌缺血的动态病理生理学.
- 突出仅仅解决氧气供需不平衡的局限性.
- 定义心肌缺血的综合治疗目标.
主要方法:
- 对心肌缺血现有文献的综述.
- 分析氧气需求,冠状动脉流和细胞反应之间的相互作用.
- 检查荷尔蒙,代谢和血液动力学因素.
主要成果:
- 心肌缺血涉及的因素的动态相互作用超出了简单的氧气失衡.
- 这些因素在缺血事件发生之前,期间和之后被不适当地改变.
- 在缺血期间建立了一个自我延续的恶性循环.
结论:
- 治疗心肌缺血的药物治疗需要一个多方面的方法.
- 治疗策略必须旨在防止缺血的发展.
- 逆转异常的荷尔蒙,代谢和血液动力学影响对于有效的治疗至关重要.
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