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岛屿细胞抗体的量化和对胰岛素依赖糖尿病的预测
E Bonifacio1, P J Bingley, M Shattock
1Department of Immunology, University College, Middlesex School of Medicine, London, UK.
Lancet (London, England)
|January 20, 1990
概括
岛屿细胞抗体 (ICA) 强烈预测未来的胰岛素依赖性糖尿病 (IDDM) 在亲属中出现. 高的ICA水平显著增加了几年内发展IDDM的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 糖尿病研究 糖尿病研究
背景情况:
- 胰岛素依赖性糖尿病患者 (IDDM) 的一级亲属具有增加的遗传倾向.
- 小岛细胞抗体 (ICA) 是对胰腺β细胞自身免疫活性的标记物.
- 早期识别患有IDDM高风险的个体对于及时干预至关重要.
研究的目的:
- 为了确定ICA对未来IDDM开发的敏感性和预测价值.
- 评估ICA水平与IDDM发病时间之间的相关性.
- 确定ICA检测的门值及其预后意义.
主要方法:
- 对719名IDDM患者的一级亲属进行了长达10.5年的预期随访.
- 使用青少年糖尿病基金会 (JDF) 单位通过间接免疫光学量化ICA.
- 对ICA检测率的分析以及与IDDM发生率和诊断时间的相关性.
主要成果:
- 在基线时,在3.3%的亲属中检测到ICA,并在随访期间再增加1.9%.
- 35%的亲属患有可检测的ICA,而没有可检测的ICA的 IDDM 患有0.3%.
- 较高的峰值ICA水平与较早的IDDM发作相关;在10年内IDDM的100%预测值在80个JDF单位以上.
结论:
- ICA是IDDM在风险人群中发展的高度敏感和预测性标志物.
- ICA的水平与IDDM进展的风险和速度成正比.
- ICA测试对于分层风险和预测受影响患者的家庭成员IDDM发病是有价值的.
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