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无氧气处理金属酶的结构功能关系

Juan C Fontecilla-Camps¹, Patricia Amara, Christine Cavazza

¹Laboratoire de Cristallographie et Cristallogenèse des Protéines, Institut de Biologie Structurale J.P. Ebel, CEA, CNRS, Université Joseph Fourier, 41 rue J. Horowitz, 38027 Grenoble Cedex 1, France. juan-carlos.fontecilla@ibs.fr

|August 14, 2009

概括

早期生命可能利用了像气和二氧化碳这样的简单气体. 类似矿物质的酶活性位点促进了这些以气体为基础的代谢反应,这对于理解生命起源至关重要.

科学领域:

生物化学和天体生物学
生命的起源研究研究研究

背景情况:

涉及诸如 (H2), (N2),一氧化碳 (CO),二氧化碳 (CO2) 和甲 (CH4) 等气体的反应被假定是生命起源的基础.
参与这些反应的酶的活性位结构往往与矿物结构有相似之处,这表明地质化学和早期生物化学之间存在联系.

研究的目的:

阐明现存微生物中基于气体的新陈代谢的合理机制.
研究酶活性位点和蛋白质矩阵在促进早期代谢途径中的作用.

主要方法:

整合蛋白质结晶学以确定酶结构.
应用各种光谱技术来研究反应中间体和动态.
利用理论计算和模型化学来模拟反应机制.

主要成果:

已经提出了基于气体的新陈代谢的可信机制.
酶活性位点,以金属离子为中心,被证明对这些反应至关重要.
蛋白质矩阵在控制基质和产品的反应性和运输方面发挥着调节作用.

结论:

由矿物质类酶活性部位促进的基于气体的代谢反应,可能是生命起源的核心.
蛋白质环境精确地调节金属中心的功能,通过内部通路,特定结合和介电效应,实现高效的基质和产品贩运.

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