化酶的机械考虑 化酶的机制考虑
1Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. butler@chem.ucsb.edu
Nature
|August 14, 2009
概括
大自然使用化来提高药物化合物的活性. 新的酶正在被发现,激活化物用于生物反应,增加药物潜力.
科学领域:
- 生物化学 生物化学
- 酶学 是一种酶学.
- 自然产品化学 自然产品化学
背景情况:
- 化增强自然化合物的生物活性,其中许多被用作药物.
- 化物需要激活,通常是通过氧化,才能变得有反应性.
- 新型化酶的发现正在加速.
研究的目的:
- 审查参与化酶的日益增长的发现.
- 要突出这些酶激活化物的机制.
- 为了强调这些酶在天然产品生物合成和药物发现中的重要性.
主要方法:
- 关于化酶的最新文献的综述.
- 根据辅因子要求对酶进行分类 (例如金属酶,酶,S-adenosyl-L-methionine依赖酶).
- 催化机制的分析,包括化物氧化和核性添加.
主要成果:
- 已经确定了越来越多能够催化化反应的多种酶.
- 这些酶利用各种辅助因子和氧化剂,如二氧化物和过氧化物.
- 机制包括直接化物氧化和核化物添加.
结论:
- 化酶的不断扩大的剧目为合成生物学和药物开发提供了新的工具.
- 了解这些酶途径对于利用它们在药物化学中的潜力至关重要.
- 持续的酶发现可能会导致具有治疗应用的新型化天然产品.
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