药物诱导的纤维性膜心脏病
Sanjeev Bhattacharyya1, Anthony H Schapira, Dimitri P Mikhailidis
1Valvular Heart Disease Clinic, Department of Cardiology, Royal Free Hospital, London, UK.
Lancet (London, England)
|August 18, 2009
概括
某些药物可以导致心脏膜疾病,风险根据药物剂量和治疗时间而增加. 医生必须权衡这些血清激素药物的益处与潜在的心脏风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 药物使用和心脏膜疾病 (VHD) 之间的联系首次在20世纪60年代通过偏头痛预防药物观察到.
- 从那时起,几种药物类别,包括食欲抑制剂,多巴胺激动剂和兴奋剂 (3,4-methylenedioxymethamphetamine; MDMA) 等娱乐性药物,与VHD有关.
- 血清能途径被认为是药物诱导的VHD的可能机制.
研究的目的:
- 审查药物使用与膜心脏病之间的关联.
- 要突出血清激素代谢在药物诱导的VHD中的作用.
- 为临床决策提供有关影响血清路的药物的风险和益处的信息.
主要方法:
- 对临床试验数据和观察性研究的审查.
- 对药物机制的分析,专注于血清素通路.
- 风险因素的评估,包括药物剂量和治疗持续时间.
主要成果:
- 药物剂量和治疗时间显著影响药物诱导的VHD的风险和严重程度.
- 虽然自然史尚不清楚,但已经报告了治疗后膜病变的回归.
- 通常处方的药物与血清路相互作用,需要持续保持警.
结论:
- 药物诱导的VHD是一个公认的临床问题,与影响血清素的药物有关.
- 医生必须仔细平衡治疗效益与VHD的风险.
- 进一步的研究对于指导治疗决策和管理服用血清激素药物的患者至关重要.
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