1,1-异位与非功能化化的催化高酶选择性直接分子间化
1Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
Journal of the American Chemical Society
|August 19, 2009
概括
一种新型的 (((I) 催化剂使得化与化能够对化进行反选择性化. 这种反应有效地产生具有高立体选择性的有价值的玛基胺.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 直接的分子间酸化是C-C键形成的关键转化.
- 在有机合成中,开发用于水酸化的酶选择性方法仍然是一个重大挑战.
研究的目的:
- 为了建立一个高度的enantioselective催化系统,用于直接的分子间酸化阿尔法替代的烯胺.
- 为了合成高产量和优异的等离子过量 (ee) 值的玛基胺.
主要方法:
- 使用了一种带有基 () 的复合物与一种性素连接体 ((R,R) -QuinoxP*).
- 作为合伙伴,使用非功能化亚利法性化物.
- 研究了反应条件,以获得最佳产量和酶选择性.
主要成果:
- 实现了高分离选择性直接分子间酸化的α替代的烯胺.
- 在高产量中获得相应的玛基胺.
- 显示出出色的等离子过量 (ee) 值,表明高度的立体控制.
结论:
- 开发的 (((I) 催化剂系统对于不对称的酸化是有效的.
- 这种方法可以有效地获取有价值的奇拉性玛基胺.
- 这项研究突出了合罗复合物的潜力,在enantioselective合成.
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