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A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
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空气温度和心肌梗塞的发生在德国奥格斯堡
Kathrin Wolf1, Alexandra Schneider, Susanne Breitner
1Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany. kathrin.wolf@helmholtz-muenchen.de
Circulation
|August 19, 2009
概括
温度的突然下降,不仅仅是寒冷的天气,增加心肌梗塞 (MI) 的风险. 这项研究发现,不寻常的温度下降与更高的心脏病发作率有关,即使是在夏天.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 气象学与公共卫生
背景情况:
- 空气温度波动与心血管疾病有关.
- 以前的研究表明,温度和心脏问题之间存在关联.
- 了解这些联系对于公共卫生战略至关重要.
研究的目的:
- 调查与空气温度有关的心肌梗塞 (MI) 率和冠状动脉死亡.
- 分析温度对德国奥格斯堡心脏病发作的影响.
- 区分即时,延迟和累积温度影响.
主要方法:
- 利用了来自奥格斯堡地区 (MONICA/KORA) 心血管疾病/合作健康研究监测趋势和决定因素 (1995-2004) 的注册数据.
- 同时收集气象数据和空气污染物度.
- 采用波桑回归分析,调整各种环境和时间因素,以评估温度对MI发生率的影响.
主要成果:
- 五天平均气温下降10°C与心脏病发作风险相对降低1.10有关.
- 致命的MI显示出与温度下降的更直接的关联,而非致命的MI则表现出延迟的模式.
- 温度下降对心脏病发作的影响在温暖的年份更为明显,并在夏季观察到.
结论:
- 温度变化和心脏病发作之间的反向关系全年存在,包括夏季.
- 这些发现表明,异常的温度下降,而不仅仅是寒冷,会影响心脏病发作率.
- 这些结果突出了温度变化对心血管事件的影响.
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