聚合物饮食与元素饮食在治疗活跃克罗恩病时的受控试验
M H Giaffer1, G North, C D Holdsworth
1Gastroenterology Unit, Royal Hallamshire Hospital, Sheffield.
Lancet (London, England)
|April 7, 1990
概括
像Vivonex这样的元素饮食对活跃克罗恩病的缓解率高于像Fortison这样的聚合物饮食. 这项为期4周的研究发现,Vivonex显著改善了患者的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 炎症性肠道疾病是什么
背景情况:
- 克罗恩氏病是一种慢性炎症性肠病.
- 活跃的克罗恩病通常需要用类固醇治疗.
- 营养治疗是关键的管理策略.
研究的目的:
- 为了比较元素与聚合物饮食在诱导活跃克罗恩病缓解的疗效.
- 在饮食干预期间评估疾病活动的临床和实验室标志物.
主要方法:
- 一项随机对照试验,涉及30名活跃克罗恩病患者.
- 患者接受了4周的元素饮食 (Vivonex) 或聚合物饮食 (Fortison).
- 临床缓解和实验室指数在10天和28天后进行评估.
主要成果:
- 在元素饮食 (75%) 与聚合物饮食 (36%) 相比,观察到显著更高的临床缓解率 (p<0.03).
- 饮食干预表明,尽管临床改善,营养状况和实验室标记物发生的变化很小.
- 基本饮食在实现缓解方面表现出卓越的疗效.
结论:
- 元素饮食比聚合物饮食更有效地诱导活跃克罗恩病患者的缓解.
- 聚合物饮食可能不是急性克罗恩病恶化的有效替代方案.
- 对克罗恩病的营养策略进行进一步的研究是有必要的.
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