在库辛病中,氨酸血管压素在库辛病中
G A Wittert1, P A Crock, R A Donald
1Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
Lancet (London, England)
|April 28, 1990
概括
较低的状鼻取样有助于通过测量上腺皮质激素 (ACTH) 和血管压素 (AVP) 梯度来横向化库辛病瘤. 一侧AVP和ACTH升高表明瘤的位置,这表明AVP在ACTH释放中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 库辛病是由过度上腺皮质激素 (ACTH) 分泌引起的,通常来自垂体小腺瘤.
- 准确的瘤定位对于有效治疗库辛病至关重要.
研究的目的:
- 评价双边同时下层状鼻取样 (BIPSS) 在库辛病中垂体小腺瘤横向化的有用性.
- 调查血管压素 (AVP) 和其他垂体激素与库辛病中ACTH分泌有关的作用.
主要方法:
- 双边同时采集的血液样本是从九名库辛氏病患者的下垂鼻中采集的.
- 测量中的激素含量包括ACTH,AVP,益乳素,生长激素,黄质化激素 (LH) 和卵泡刺激激素 (FSH).
- 间阴影梯度被计算出来以确定瘤横向化.
主要成果:
- 在9名患者中,ACTH和AVP梯度正确地侧向了7名患者的微腺瘤.
- 一名患者显示AVP梯度,但瘤侧没有ACTH梯度.
- 在排水石鼻腔中发现AVP和ACTH度之间存在显著的相关性.
- 瘤侧的益生素和生长激素水平也升高,而LH和FSH梯度通常不显著.
结论:
- 在库辛病中,BIPSS有效地横向化垂体微腺瘤,特别是使用ACTH和AVP梯度.
- 瘤侧AVP水平升高表明与皮质otropin释放因子的潜在相互作用,促进瘤生长和ACTH释放.
- 这些发现表明,异常的血液供应有助于局部AVP输送,影响库辛氏病中的垂体功能.
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