定义可以实现生化适应的网络拓
Wenzhe Ma1, Ala Trusina, Hana El-Samad
1Center for Theoretical Biology, Peking University, Beijing 100871, China..
Cell
|August 26, 2009
概括
这项研究确定了两个核心酶网络拓,负反循环和不连贯的前循环,使生物系统能够适应. 这些基本设计对于理解和设计蜂信号网络至关重要.
科学领域:
- 系统生物学 系统生物学
- 生化网络分析 生物化学网络分析
- 酶动力学 酶动力学
背景情况:
- 细胞信号系统经常表现出适应性,即在刺激反应后重置的能力.
- 了解使适应成为可能的基本网络结构是解读生物复杂性的关键.
研究的目的:
- 以计算方式识别所有可能的能够执行适应的三节点酶网络拓.
- 确定核心网络模式,以确保生物信号的稳健适应.
主要方法:
- 所有三节点酶网络拓学的详尽的计算搜索.
- 分析网络动态,以识别表现出适应性行为的结构.
主要成果:
- 确定了两个主要的核心适应拓:带有缓冲的负反循环和带有比例的不连贯的前循环.
- 包含这些拓的最小电路足以在特定参数范围内进行适应.
- 复杂的自适应网络总是包含至少一个这些核心拓.
结论:
- 一组有限的核心网络拓构成了跨多种生化网络的适应功能的基础.
- 这些发现为分类自然网络和工程合成网络提供了设计框架.
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