美国的伤寒热,1999-2006年
Michael F Lynch1, Elizabeth M Blanton, Sandra Bulens
1Enteric Diseases Epidemiology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F-22, Atlanta, GA 30341, USA. mlynch1@cdc.gov
JAMA
|August 27, 2009
概括
美国的抗菌素耐药型沙门氏菌感染与旅行有关,特别是在印度次大陆. 对纳利迪克斯酸的耐药性和降低诺基诺敏感性正在增加对伤寒发烧的担忧.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生监督 公共卫生监督
背景情况:
- 美国的伤寒热越来越多地是由耐药沙门氏菌引起的.
- 国家监测对于指导预防和治疗策略至关重要.
研究的目的:
- 分析对抗微生物药物耐药的沙门氏菌 (S. Typhi) 感染的趋势.
主要方法:
- 一项基于实验室的横截面研究分析了1999-2006年的数据.
- 包括1902例伤寒病例和2016年的S. Typhi分离体,测试了对抗菌素敏感性的测试.
- 检查了耐药性比例和耐药性感染的患者风险因素.
主要成果:
- 对多种药物耐药的S. Typhi (MDRST) 和对酸耐药的S. Typhi (NARST) 分别在13%和38%的分离物中被发现.
- 在1999年至2006年期间,NARST比例从19%增加到54%.
- 去印度次大陆的旅行与MDRST (OR 7.5) 和NARST (OR 20.4) 感染有很强的联系.
结论:
- 美国患者的抗菌素耐药性S. Typhi感染与前往印度次大陆的旅行有关.
- 越来越多的S. Typhi与降低诺基诺隆敏感性的增长率是一个越来越令人担忧的问题.
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