新药用于慢性阻塞性肺病的恶化
Trevor T Hansel1, Peter J Barnes
1National Heart and Lung Institute, Imperial College, London, UK. t.hansel@imperial.ac.uk
Lancet (London, England)
|September 1, 2009
概括
慢性阻塞性肺病 (COPD) 是一种由感染和吸烟驱动的先天性免疫疾病. 了解COPD 的理解
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 烟草吸烟是慢性阻塞性肺病 (COPD) 的主要危险因素.
- 病毒和细菌感染是COPD恶化的主要原因.
- 活性氧物种 (ROS),病原体相关分子模式 (PAMPs) 和损伤相关分子模式 (DAMPs) 激活模式识别受体 (PRRs),包括收费类受体 (TLRs).
研究的目的:
- 探索COPD是先天免疫的原型疾病的假设.
- 描述COPD中异常免疫反应的特征.
- 为了确定COPD预防和治疗的分子标.
主要方法:
- 对现有文献的审查和对COPD先天免疫路径的理解.
- 分析COPD的特征,包括屏障功能,急性阶段反应和免疫细胞激活.
- 检查相关疾病,如皮质类固醇耐药性和异常修复过程.
主要成果:
- 慢性肺炎的特征是对受伤的异常天生的免疫反应.
- 关键特征包括呼吸道屏障功能的改变,急性相反应和巨细胞,中性粒细胞和纤维细胞的过度激活.
- 这种疾病包括炎症,修复,纤维化,蛋白质溶解,皮质类固醇耐药性和缺陷再生.
结论:
- 基本上,COPD是一种先天性免疫系统疾病.
- 了解这些免疫机制为开发新的治疗策略提供了基础.
- 目前正在进行临床试验,以寻找有效的药物来预防和治疗COPD恶化.
相关概念视频
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