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ErbB2类似于一种自身抑制的无脊椎动物表皮生长因子受体

Diego Alvarado1, Daryl E Klein, Mark A Lemmon

  • 1Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6059, USA.

Nature
|September 1, 2009
PubMed
概括

孤儿受体氨酸激酶ErbB2 (HER2) 可能受到类似于Drosophila melanogaster EGFR (dEGFR) 的配体的调节. 这一发现挑战了ErbB2缺乏自身抑制的概念,并为癌症提供了新的治疗点.

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