交叉链接的高分支多糖醇作为客分子选择性结合的宿主
Ewelina Burakowska1, Jordan R Quinn, Steven C Zimmerman
1Department of Biology, Chemistry, and Pharmacy, Freie Universitat Berlin, Takustrasse 3, 14195 Berlin, Germany.
Journal of the American Chemical Society
|September 3, 2009
概括
与格鲁布斯催化剂交叉链接的高分支多糖醇 (HPG) 产生了选择性复杂的材料,并释放了像孟加拉这样的染料,显示了对刺激响应应用的潜力.
科学领域:
- 聚合物化学 聚合物化学
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
背景情况:
- 环闭转化反应使树枝状体变硬.
- 超分支多糖醇 (HPG) 可以用于复杂化.
- 染料复杂化和释放是响应性材料的关键.
研究的目的:
- 用各种染料研究改性高分支多糖醇 (HPG) 的复合和释放行为.
- 探索交叉链接和化学修饰对HPG客结合性质的影响.
- 评估这些HPG材料在刺激响应应用中的潜力.
主要方法:
- 使用格鲁布斯催化剂合成聚化HPG (1) 和其交联类型 (2,5,6).
- 复杂化研究与孟加拉和蒂摩尔蓝的盐和孟加拉和蒂摩尔蓝的盐.
- 基基的二基化产生HPG 3,4,7和8.
- 使用UV-Vis光谱学,动态光散射 (DLS) 和尺寸排除色谱 (SEC) 的表征.
主要成果:
- HPG 1 复合物在甲中释放孟加拉,但在水中释放.
- 交叉链接的HPG2复合体孟加拉和青,但不会在水中释放它们.
- 较大的循环交联类型 (5,6) 结合色孟加拉和胸膜蓝色,更容易释放它们.
- HPG 4 形成大型聚合物 (大约 100nm) 在水中,在高度盐分离.
结论:
- 交联密度和循环大小显著影响着染料复合和释放动力学.
- 修改的HPG对各种染料对象具有不同的结合亲和力.
- 观察到的HPG 4的盐响应聚合表明了对刺激响应材料设计的潜力.
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