黄金纳米颗粒与加多酸功能化,作为高放松度MRI对比剂
Loïck Moriggi1, Caroline Cannizzo, Eddy Dumas
1Institut des Sciences et Ingénieurie Chimique, Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland.
Journal of the American Chemical Society
|September 3, 2009
概括
偏磁的加多功能化黄金纳米粒子对MRI对比度具有很高的放松性. 它们的小尺寸 (2-15纳米) 和水中的分散性使得它们对成像应用非常有希望.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学成像技术 生物医学成像技术
背景情况:
- 偏磁纳米粒子对于增强磁共振成像 (MRI) 的对比度至关重要.
- 基于加多的药物被广泛使用,但对毒性和稳定性存在担忧.
- 开发新的纳米粒子平台为改进的MRI对比剂提供了机会.
研究的目的:
- 为了合成和表征与加多功能化的水可分散的金纳米粒子.
- 评估这些新型纳米粒子的磁性和放松性.
- 评估它们作为MRI对比剂的潜力.
主要方法:
- 金纳米颗粒的合成.
- 使用加多合物合物的功能化.
- 使用传输电子显微镜 (TEM) 和动态光散射 (DLS) 进行表征.
- 测量核磁放松分散 (NMRD) 形状的测量.
主要成果:
- 成功合成了水中可分散的金纳米粒子,尺寸从2到15纳米不等.
- 实现了高放松度,这表明MRI中信号显著增强.
- 证明金芯对磁矩没有实质性的贡献,加多是主要来源.
结论:
- 加多功能化黄金纳米粒子代表了一类有前途的MRI对比剂.
- 它们的调节大小和高放松性为各种成像应用提供了优势.
- 进一步调查它们的体内性能和安全性是有必要的.
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