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Updated: Jun 20, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
12:19

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

由C4'-氧化基底部部位形成跨链的范围和机制

Jonathan T Sczepanski1, Aaron C Jacobs, Ananya Majumdar

  • 1Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

Journal of the American Chemical Society
|September 3, 2009
PubMed
概括

在C4'-氧化基底部部位 (C4-AP) 的DNA损伤形成了两种类型的跨链交叉链 (ICL). 序列背景显著影响ICL的形成和稳定性,可能导致细胞损伤.

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