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通过逆转录病毒介导的基因转移纠正CD18缺乏的淋巴细胞

J M Wilson1, A J Ping, J C Krauss

  • 1Howard Hughes Medical Institute, Department of Internal Medicine, Ann Arbor, MI.

Science (New York, N.Y.)
|June 15, 1990
PubMed
概括

白细胞粘附缺陷 (LAD) 是一种遗传性免疫障碍. 使用逆转录病毒的基因治疗成功地纠正了患者淋巴细胞中的CD18基因缺陷,恢复了正常的免疫细胞功能.

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...