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KDM1B是一种基因组H3K4脱甲基酶,需要建立母体基因组印记

David N Ciccone1, Hui Su, Sarah Hevi

  • 1Epigenetics Program, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Nature
|September 4, 2009
PubMed
概括

氨酸脱甲基酶1B (KDM1B) 对于在卵细胞发育过程中在印记的基因上建立DNA甲基化印记至关重要. 它的缺失导致异常的基因表达和小鼠的胚胎致死性.

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