在除掉心房动后的抗节律药物 (5A研究)
Jean-François Roux1, Erica Zado, David J Callans
1Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Circulation
|September 10, 2009
概括
经验性抗心律失常药物 (AAD) 治疗六周后心房动 (AF) 移除显著减少心房失常和住院治疗. 这种治疗耐受性很好,改善了AF切除后患者的治疗结果.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在心房动 (AF) 移除后,心房律乱经常发生在早期.
- 这项研究调查了实证抗心律失常药物 (AAD) 治疗在缓解这些早期的脱离后心律失常症方面的疗效.
研究的目的:
- 为了确定经验性抗节律药物 (AAD) 治疗的6周疗程是否可以减少AF切除后心房律乱的发生率.
- 评估这种预防性AAD治疗方案的安全性和耐受性.
主要方法:
- 一项随机对照试验,涉及110名接受AF切除的患者.
- 患者被分配给接受经验AAD治疗或没有抗心律失常疗法在第一个6周后的ablation.
- 通过电话监控器进行持续监测和6周的临床评估.
主要成果:
- 在AAD组中,较少的患者经历了初级复合终点 (19%对42%;P=0.005).
- 在AAD组中,临床显著的事件,包括AF>24小时或心律失常相关的住院治疗/心脏转变,减少了 (13%对28%;P=0.05).
- 抗阿尔茨海默症治疗耐受性良好,因不耐受性而导致药物戒药没有显著差异.
结论:
- 在AF切除后6周的经验性抗心律药物 (AAD) 治疗是安全有效的.
- 这一策略显著降低了临床相关心房律不整的发生率,减少了心脏转移和住院治疗的需要.
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