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Endocarditis IV: Nursing Management
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一种光性上皮干细胞,是前列腺癌的起源细胞
Xi Wang1, Marianna Kruithof-de Julio, Kyriakos D Economides
1Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Nature
|September 11, 2009
概括
研究人员确定了一种新的前列腺干细胞群体,称为耐化NKx3-1表达细胞 (CARNs),对前列腺再生至关重要,是前列腺癌的潜在来源.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 干细胞生物学 干细胞生物学
- 癌症研究 癌症研究
背景情况:
- 前列腺癌的起源来自正常的祖先细胞仍然不清楚.
- 了解干细胞种群是了解组织再生和癌症发展的关键.
研究的目的:
- 识别和描述参与再生的前列腺干细胞.
- 研究nkx3-1在前列腺干细胞维护和功能中的作用.
- 确定已识别的干细胞是否是前列腺癌发病的目标.
主要方法:
- 在小鼠中的遗传谱系标记.
- 单细胞移植试验. 单细胞移植试验.
- 在前列腺再生过程中对Nkx3-1突变小鼠的分析.
- 在已识别的干细胞中向删除Pten瘤抑制基因.
主要成果:
- Nkx3-1标志着干细胞群 (CARNs) 在前列腺再生期间活跃.
- 卡恩是双潜在的,自我更新,可以重建前列腺组织.
- Nkx3-1对于维持前列腺干细胞功能至关重要.
- 在CARNs中的Pten删除导致迅速的前列腺癌形成.
结论:
- 卡恩细胞代表前列腺中一种新型的发光干细胞群.
- 这种干细胞群对于前列腺再生至关重要.
- 卡恩是瘤转变的高效目标,推动前列腺癌的发展.
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