无症状的鹿在便中分泌传染性子
Gültekin Tamgüney1, Michael W Miller, Lisa L Wolfe
1Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143 USA.
Nature
|September 11, 2009
概括
无症状的鹿在表现出症状之前在便中分泌传染性子. 慢性衰竭疾病 (CWD) 在便中的这种长期泄露的子为鹿群中疾病传播提供了一个机制.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 神经科学是一个神经科学.
- 野生动物生态生态学
背景情况:
- 传染性病,如甲虫病和慢性衰竭病 (CWD),在动物群体内自然传播.
- 症状动物中的传染源已知,但它们在流行病中的作用尚不清楚.
研究的目的:
- 为了研究无症状动物的离子泄露.
- 确定便在慢性衰竭疾病 (CWD) 传播中的作用.
主要方法:
- 鹿 (Odocoileus hemionus) 在便中被监测到子分泌.
- 来自无症状鹿的便样本被注射到过度表达羊蛋白 (PrP) 的转基因小鼠中.
主要成果:
- 在15个无症状鹿便样本中的14个中检测到传染性CWD子.
- 在临床症状出现前7至11个月,子被释放出来.
- 便中总的子排泄量可能与疾病过程中的大脑子负载相近.
结论:
- 无症状的CWD子在便中的泄露是疾病传播的重要因素.
- 长时间的便流放为鹿群中CWD流行病提供了一个合理的机制.
- 这突出了鹿类之间水平子传播的关键途径.
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