分子网络作为常见人类疾病的传感器和驱动器
1Pacific Biosciences, 1505 Adams Drive, Menlo Park, California 94025, USA. eschadt@pacificbiosciences.com
Nature
|September 11, 2009
概括
基因组学革命使得分子生物学与生理学的联系成为可能. 反向工程分子网络通过将DNA和环境因素与生理变化联系起来,有助于理解疾病.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 系统生理学 系统生理学
- 临床医学 临床医学
背景情况:
- 分子生物学革命的重点是DNA,RNA和蛋白质生物合成,导致理解整个系统生理学的差距.
- 这种分子焦点阻碍了基础科学发现与临床医学的整合.
研究的目的:
- 为了弥合分子生物学和临床医学之间的差距.
- 为了利用基因组学工具逆向工程分子网络.
- 为了将分子状态与疾病的生理变异联系起来.
主要方法:
- 利用基因组学革命中的工具.
- 分子网络的逆向工程.
- 分析网络如何感知DNA和环境干扰.
主要成果:
- 建立了一个框架,将分子状态与生理结果联系起来.
- 证明了分子网络在感知扰动中的作用.
- 确定了驱动与疾病相关的生理变异的途径.
结论:
- 基因组学提供了将分子见解与生理状态联系起来的工具.
- 反向工程分子网络是了解疾病机制的关键.
- 这种方法有助于将分子生物学转化为临床应用.
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