mitra valve 叶片矩阵组成的显著变化和与心动节拍引起的心肌病变的周转率
Elizabeth H Stephens1, Tomasz A Timek, George T Daughters
1Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.
Circulation
|September 16, 2009
概括
扩张性心肌病 (DCM) 显著重塑了对心肌 (MV) 的说明书,改变了它们的组成和结构. 这项研究揭示了DCM小册子中细胞密度和细胞外矩阵周转率的增加,影响了门功能.
科学领域:
- 心血管研究研究心血管研究
- 生物医学工程 生物医学工程
- 细胞外矩阵生物学 细胞外矩阵生物学
背景情况:
- 扩张性心肌病 (DCM) 导致左心室重塑,但对关 (MV) 传单的变化知之甚少.
- 在DCM中研究MV传单重塑对于了解疾病进展至关重要.
研究的目的:
- 在DCM模型中评估矩阵组成和MV传单内的营业额的变化.
- 描述由于DCM而导致的MV传单中的结构和细胞变化.
主要方法:
- 在24只绵羊中建立了一种心动节拍诱导心肌病 (TIC) 模型.
- 双飞机视频光学和免疫组织化学被用来分析MV传单的结构和组成.
- 细胞密度的量化,细胞外矩阵组件和肌纤维细胞表型在传单部分.
主要成果:
- 在TIC组的诱导后, mitra反显著增加.
- 与对照组相比,TIC传单显示细胞密度增加和分层结构破坏.
- 在TIC小册子中观察到原和弹性纤维的增加,以及肌纤维细胞表型的增加.
结论:
- 在DCM中,中枢的小册子经历了显著的重塑,影响了细胞的组成,结构和细胞表型.
- 了解DCM诱导的叶片力学变化和细胞介导的细胞外矩阵重塑是未来治疗策略的关键.
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