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从不同患者的骨髓细胞中鉴定与低血管新生功效相关的风险因素

Tao-Sheng Li¹, Masayuki Kubo, Kazuhiro Ueda

¹Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan. litaoshe@yamaguchi-u.ac.jp

|September 16, 2009

概括

一个新的评分系统预测了骨髓细胞治疗缺血性疾病的有效性. 该工具可以识别可能从细胞疗法中受益的患者,从而改善治疗结果.

科学领域:

再生医学是一种再生医学.
血管生物学血管生物学
生物标志物生物标志物

背景情况:

自主骨髓衍生细胞促进治疗性血管生成,用于缺血性疾病.
患者的治疗结果差异很大,需要患者分层以获得最佳治疗.

研究的目的:

为了确定与骨髓细胞的血管新生功效差相关的风险因素.
开发一个预测评分系统,用于选择患者进行基于细胞的疗法.

主要方法:

收集了从25名接受椎切割的患者的临床和实验室数据.
在体外和体内评估骨髓细胞质量和血管新生功效 (小鼠缺血肢体模型).
与细胞强度相关的患者因素 (年龄,功能衰竭,贫血,脂质概况,炎症标志物).

主要成果:

骨髓细胞的血管新生功效在患者之间有显著差异.
衰老,功能衰竭,贫血,高甘油三,CRP,IL-6和NTX水平与细胞功率降低相关.
结合这些因素的风险评分强烈预测了血管新生功效 (r=-0.883,P<0.001),准确度为80%.

结论:

确定了骨髓细胞血管新生功能的降低的主要风险因素.
开发了一种新的评分系统,用于预测治疗性血管生成的细胞效能.
评分系统可以帮助选择合适的患者进行临床试验,包括用于缺血性疾病的细胞植入.

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