在接受冠状动脉旁路移植的八十多岁人群中评估再血管化亚型
Abdulhameed Aziz1, Anson M Lee, Michael K Pasque
1Washington University School of Medicine, St. Louis, MO 63110-1013, USA.
Circulation
|September 16, 2009
概括
在八十多岁的人中,完整的冠状动脉旁路移植重血管化对于长期生存至关重要. 避免不完整的重血管化显著改善了结果,尽管功能性完整的重血管化与传统方法相比没有额外的生存益处.
科学领域:
- 心血管外科心血管外科
- 老年医学 老年医学
- 临床结果研究研究
背景情况:
- 经过冠状动脉旁路移植 (CABG) 手术的八分生殖器患者的长期存活率根据重血管化的完整性而有所不同.
- 定义的定义的定义.
- 完整的完整的完整的完整的
- 重新血管化的过程.
- 是不一致的,复杂的生存数据解释.
- 这项研究对重血管化亚型进行了分层分层,以澄清八岁人群的生存率.
研究的目的:
- 为了评估冠状动脉旁路移植 (CABG) 手术后八十多岁患者的长期生存率.
- 为了比较功能完整,传统完整和不完整的复血管化策略之间的生存结果.
- 为了确定更全面的重血管化方法是否能改善这一老年人群的存活率.
主要方法:
- 对580名八十岁患者 (80-94岁) 的回顾性分析,这些患者在1986年至2007年期间接受了CABG.
- 患者被分为功能完整 (所有患病血管的移植>50%狭窄),传统完整 (每个主要动脉系统的移植>50%狭窄) 和不完整的再血管化组.
- 使用卡普兰-梅尔分析评估了长期存活率,第二次分析排除了存活率小于12个月的患者,以尽量减少选择偏差.
主要成果:
- 在580名患者中,48%的患者有功能完整,31%的患者有传统完整,21%的患者有不完整的血管恢复.
- 功能性 (6.8年) 和传统 (6.7年) 完全重血管化组之间的长期存活率相似 (P=0.51).
- 不完整的重血管化与显著减少的生存率 (4.2年,P=0.007) 相关,即使排除了短期幸存者 (P=0.04),生存率仍然存在.
- 五年生存率为59% (功能性),57% (传统) 和45% (不完整).
- 八年生存率为40% (功能性),37% (传统) 和26% (不完整).
结论:
- 功能性完整的血管再循环并没有在八十岁人群中比传统的完整血管再循环提供显著的长期生存优势.
- 不完整的重血管化与较差的长期存活率有关,这可能是由于更广泛的冠状动脉疾病.
- 避免不完全的再血管化对于改善CABG接受CABG的八十岁人群的生存至关重要,但对功能完整性的额外努力并不能进一步提高生存率.
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