对心室重塑进行心交叶片的适应:对缺血性心交叶片吐模型的未来变化
Miguel Chaput1, Mark D Handschumacher, J Luis Guerrero
1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Circulation
|September 16, 2009
概括
心脏病发作后心脏膜面积增加,但这种适应不能完全防止泄漏. 了解这种门重塑,为缺血性 mitrale 吐提供了潜在的新治疗点.
科学领域:
- 心脏病学 心脏病学
- 心脏机械学 心脏机械学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 缺血性 mitra 反 (IMR) 源于心室扭曲,导致 mitra 叶片的缩绑定.
- 由于测量挑战,IMR中的传单面积调整是不太了解的.
- 之前的研究表明,IMR患者的叶片面积增加,与更少的反相关.
研究的目的:
- 为了研究同一个心脏中心交膜区域的纵向变化,经历IMR.
- 为了确定随着时间的推移中枢面积的适应是否可以弥补IMR中的心室重塑.
主要方法:
- 使用3D心声学测量12只羊的心肌甲状腺叶片面积在基线和下心肌梗塞后3个月.
- 将未经治疗的羊 (n=6) 与用心上贴片治疗的羊 (n=6) 进行比较,以限制左心室扩张.
主要成果:
- 未经治疗的羊表现出显著的左心室扩张,全局功能障碍和中度的IMR.
- 在未经治疗的绵羊中,总的透静心交叉叶片面积显著增加 (13.1至18.1厘米2).
- 被补丁的羊保持了类似于基线的叶片面积,保持了心室功能和最小的反.
结论:
- 随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的左心室重塑,伴随着心肌梗塞后的心肌梗塞后的心肌梗塞后的心肌梗塞后的心肌梗塞后的心肌梗塞后的心肌梗塞.
- 这种传单面积的增加不足以完全抵消绑定并防止IMR.
- 澄清适应机制可能会揭示IMR的新疗法策略.
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