没有母亲基因与孕前/孕敏感性和HLA DRβ之间密切联系
A N Wilton1, D W Cooper, S P Brennecke
1School of Biological Sciences, Macquarie University, New South Wales, Australia.
Lancet (London, England)
|September 15, 1990
概括
孕产妇表达的妊娠前/妊娠前基因与人类染色体6上的HLA区域没有密切联系. 遗传分析排除了联系,表明这些易受性基因位于染色体的其他地方.
科学领域:
- 人类遗传学 人类遗传学
- 生殖医学是一种生殖医学.
- 免疫遗传学 免疫遗传学
背景情况:
- 孕前/孕后是怀孕中可能存在遗传部件的疾病.
- 孕产妇表达的敏感性基因被假设起到了作用.
- 染色体6上的人类白细胞抗原 (HLA) 区域是候选区域,因为它在免疫功能中的作用.
研究的目的:
- 调查孕产妇表达的孕产妇前/孕产妇敏感性基因与染色体6上的HLA区域之间的潜在联系.
- 为了确定HLA DRβ位点内的遗传标记是否与这些疾病有关.
主要方法:
- 类型化HLA DRβ限制片段长度多态度使用TaqI在10个多个案例的谱系中进行消化.
- 使用LIPED进行LOD分数和重组分数异质性的程序的遗传数据分析.
- 应用受影响的兄弟姐妹和受影响的血统成员方法来评估联系.
主要成果:
- 排除了HLA DRβ位点和对子宫前/子宫的敏感性之间的密切联系.
- 如果敏感性基因位于6号染色体上,则它们距离HLA DRβ位点至少距离5 centiMorgan.
- 即使在更高的重组分数中,也没有发现联系的证据.
结论:
- 影响孕前黄昏症/黄昏症易感性的主要母性表达基因不在染色体6的HLA区域内.
- 这一发现有助于缩小对导致这些妊娠障碍的遗传因素的搜索范围.
- 需要进一步的研究,以确定特定的基因和染色体位置,负责先兆子/兆子易感性.
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